Research services

Vertidiag leverages its technological and scientific platform to offer a customized R&D service to meet the needs of its clients in the field of vertigo research.

Thanks to more than 50 years of accumulated expertise, Vertidiag offers three types of services:

Troubles Vestibulaires

Safety test

Testing the safety of drug candidates on the vestibular sphere

Différents types de propositions Grace à plus de 50 années d’expertise cumulées et sa plateforme technique labellisée, VERTIDIAG propose une activité de service dans le domaine de l’otoneurologie.

Proof of concept

Establish evidence of antivertigo properties of drug candidates

Mechanism of action

Understand and locate the mechanisms and sites of action of drug candidates

The tests are conducted on a research facility certified by the health services of the Centre National de la Recherche Scientifique (CNRS) and governed by the European ethical and health codes in force, under the supervision of the Ethics Committee of the Southern Region (CE71).

Safety tests

The term ototoxicity refers to the deleterious or toxic effects on the inner ear (including the cochlea and vestibule) of natural or pharmaceutical compounds. Ototoxic damage can lead to hearing loss and vestibular disorders.

Vertidiag uses different methods and models to evaluate the ototoxic properties of drug candidates.

Technical Data Sheets : (available on request)

  • Functional and histological evaluation of the ototoxicity of a drug candidate in vivo
  • Functional and histological evaluation of the ototoxicity of a drug candidate in vitro

Proof of concept

Vertidiag has developed a technical platform to induce controlled vestibular disorders and to measure their functional impacts. This platform uses behavioural pharmacology to evaluate the potential benefits of natural or pharmacological compounds on acute vertigo, vestibular compensation and cognitive deficits. Vertidiag has a battery of behavioral tests to quantify normal and pathological vestibular function.

Technical Data Sheets : (available on request)

  • Animal models of vestibular disorders
  • Paradigms for the evaluation of fonctional impairments
 
 
 

Mechanisms of action

In addition to its in vivo models of vestibular disorders, Vertidiag possess a battery of cellular and molecular biology tools enabling it to locate and understand the mechanisms and sites of action of drug candidates. The search for these mechanisms can be carried out at the peripheral vestibular sphere (vestibular sensors and Scarpa’s ganglion) and/or the central sphere (vestibular nuclei). Understanding these mechanisms can be done on structural neuroplasticity (synaptogenesis and neurogenesis), on the modulation of neuronal excitability, on neurochemical modulation (action on neurotransmitter, hormonal and growth factor systems) or on the modulation of neuroinflammation.

Technical Data Sheets : (available on request)

  • Co-cultures of Scarpa nodes and rodent vestibular sensory organs
  • Preparation of isolated primary vestibular neurons and ex-vivo isolated vestibules
  • Histological evaluation of molecular targets of interest